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desvenlafaxine will enhance the level or result of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Watch. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, 400 mg) lower the CYP2D6 substrate dose by approximately 50%; no dosage adjustment needed with desvenlafaxine doses seven consecutive days quickly just